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{{Byline |last=O'Neill Hooker |first=Maureen |abstract=Cancer is a recurring theme in Mailer’s fiction. He believed that malignancy begins with a single defective cell that attacks a healthy body from inside. Mailer believed that spontaneous action requires courage, a feeling synonymous with guts and bravery and audacity. He also believed that the failure to act, or the failure of a courageous attempt to act, causes cancer.|url=...}}
{{Byline |last=O'Neill Hooker |first=Maureen |abstract=Cancer is a recurring theme in Mailer’s fiction. He believed that malignancy begins with a single defective cell that attacks a healthy body from inside. Mailer believed that spontaneous action requires courage, a feeling synonymous with guts and bravery and audacity. He also believed that the failure to act, or the failure of a courageous attempt to act, causes cancer.|url=...}}


{{dc|dc=T|HERE IS NO QUESTION THAT NORMAN MAILER BELIEVED}} in the toxic effects of anger unexpressed. Why else would he, a talented handyman and carpenter, build his own orgone accumulator? In the six-foot tall phone booth-sized
{{dc|dc=T|HERE IS NO QUESTION THAT NORMAN MAILER BELIEVED}} in the toxic effects of anger unexpressed. Why else would he, a talented handyman and carpenter, build his own orgone accumulator? In the six-foot tall phone booth-sized box, lined and padded with foam rubber, he wailed and banged out his personal version of scream therapy in order to de-stress from life in the fast lane.{{sfn|Bosworth|2008|p=401}} It is entirely possible that this activity protected his health in two important ways: first, it reduced his stress, and second, he ''believed'' that it reduced his stress. It may have even helped to clarify his thoughts regarding the origin of cancer and its infrequency in schizophrenics.
box, lined and padded with foam rubber, he wailed and banged out his personal version of scream therapy in order to de-stress from life in the fast lane(Bosworth 401). It is entirely possible that this activity protected his health in two important ways: first, it reduced his stress, and second, he ''believed''
that it reduced his stress. It may have even helped to clarify his thoughts regarding the origin of cancer and its infrequency in schizophrenics.


J. Michael Lennon recently made a startling discovery. It was a single page of twenty-five lines, handwritten by Mailer, probably in the early 1960s, which hypothesized that impotent emotion causes cancer. As examples of impotent emotion, Mailer described an ugly woman who waited in vain for a beautiful lover, a poor man who wished disaster upon his rich relatives,
J. Michael Lennon recently made a startling discovery. It was a single page of twenty-five lines, handwritten by Mailer, probably in the early 1960s, which hypothesized that impotent emotion causes cancer. As examples of impotent emotion, Mailer described an ugly woman who waited in vain for a beautiful lover, a poor man who wished disaster upon his rich relatives, and a person who carried within his heart a desire to murder, an obsession he would never translate into action. Mailer stated that when inner tension becomes acute, cells exist at the edge of rebellion and the violence they cannot express is suffered within. He claimed that stress caused by unexpressed anger results in cancer.{{sfn|Mailer|n.d.}} Decades before it was scientifically studied and confirmed, he wrote of the existence of switches that activate the disease.{{pg|445|446}}
and a person who carried within his heart a desire to murder, an obsession he would never translate into action. Mailer stated that when inner tension becomes acute, cells exist at the edge of rebellion and the violence they cannot express is suffered within. He claimed that stress caused by unexpressed anger results in cancer (Mailer, “Note”). Decades before it was scientifically
studied and confirmed, he wrote of the existence of switches that activate the disease.{{pg|445|446}}
In fact, cancer is a recurring theme in Mailer’s fiction. He believed that
In fact, cancer is a recurring theme in Mailer’s fiction. He believed that
malignancy begins with a single defective cell which attacks a healthy body from inside. Dougy Madden, in ''Tough Guys Don’t Dance'', knew immediately when his cancer began. After being shot, he chased his assailant for six blocks;
malignancy begins with a single defective cell which attacks a healthy body from inside. Dougy Madden, in ''Tough Guys Don’t Dance'', knew immediately when his cancer began. After being shot, he chased his assailant for six blocks; when he found himself in front of St. Vincent’s Hospital, he stopped. Instead of continuing the chase, Dougy went inside and grabbed an orderly by the collar.
when he found himself in front of St. Vincent’s Hospital, he stopped. Instead of continuing the chase, Dougy went inside and grabbed an orderly by the collar.


“[J]ust at the moment when I got tough with that punk in the white jacket was when I felt the first switch get thrown in the cancer” (Tough 158). In that
“[J]ust at the moment when I got tough with that punk in the white jacket was when I felt the first switch get thrown in the cancer.”{{sfn|Mailer|1984|p=158}} In that instant, according to Dougy’s self-revelation, he “lost his balls” and became the victim of impotent emotion.
instant, according to Dougy’s self-revelation, he “lost his balls” and became the victim of impotent emotion.


A ''Mademoiselle'' magazine interview by Eve Auchincloss and Nancy Lynch in February of 1961 is featured in “Conversations with Norman Mailer,” edited by J. Michael Lennon. It quotes Mailer saying, “It’s not living in certain
A ''Mademoiselle'' magazine interview by Eve Auchincloss and Nancy Lynch in February of 1961 is featured in “Conversations with Norman Mailer,” edited by J. Michael Lennon. It quotes Mailer saying, “It’s not living in certain courageous moments that gives one cancer.” He continues,  
courageous moments that gives one cancer.” He continues,  
<blockquote>The tragedy of it all is that if you choose to be brave at a certain moment and you fail, that’s even more likely to give you cancer than not doing anything at all. And since everyone has lost faith and a sense of certain values nobody acts any more. And more and more courageous moments are being lost all over the world, particularly in this country. And for that reason cancer is spreading. One of the causes of cancer must be the absence of action.{{sfn|Mailer|1988|p=42-43}}</blockquote>
<blockquote>The tragedy of it all is that if you choose to be brave at a certain moment and you fail, that’s even more likely to give you cancer than not doing anything at all. And since everyone has lost faith and a sense of certain values nobody acts any more. And more and more courageous moments are being lost all over the world, particularly in this country. And for that reason cancer is spreading. One of the causes of cancer must be the absence of action. (“Interview” –)</blockquote>
Later in the ''Mademoiselle'' interview, Mailer suggests that Americans no longer believe in their innate ability to rise to the demands of the moment. He associates their lack of confidence to a generation’s lack of courage and
Later in the ''Mademoiselle'' interview, Mailer suggests that Americans no longer believe in their innate ability to rise to the demands of the moment. He associates their lack of confidence to a generation’s lack of courage and
ties both to the increasing prevalence of cancer. Courage is an instinctive reaction
ties both to the increasing prevalence of cancer. Courage is an instinctive reaction that occurs in a moment fraught with danger and risk when there is
that occurs in a moment fraught with danger and risk when there is
no time for preparation and the outcome is uncertain. If an ax-wielding
no time for preparation and the outcome is uncertain. If an ax-wielding
madman chases you across a bridge and you throw yourself over the side in time to land on the deck of a passing barge, your courage has saved you. But the opportunity to jump existed in a flash of wild exhilaration and would have disappeared if you had hesitated for an instant to consider the impulse.
madman chases you across a bridge and you throw yourself over the side in time to land on the deck of a passing barge, your courage has saved you. But the opportunity to jump existed in a flash of wild exhilaration and would have disappeared if you had hesitated for an instant to consider the impulse.


Mailer believed that spontaneous action requires courage, a feeling
Mailer believed that spontaneous action requires courage, a feeling{{pg|446|447}}synonymous with guts and bravery and audacity. He also believed that the failure to act, or the failure of a courageous attempt to act, causes cancer.
{{pg|446|447}}synonymous with guts and bravery and audacity. He also believed that the failure to act, or the failure of a courageous attempt to act, causes cancer.


In 1974 Dr. Robert Ader, an experimental psychologist, gave lab rats sugar water and a nausea inducing drug called Cytoxin. As soon as the rats were conditioned to associate sweet water with a stomachache, the Cytoxin was
In 1974 Dr. Robert Ader, an experimental psychologist, gave lab rats sugar water and a nausea inducing drug called Cytoxin. As soon as the rats were conditioned to associate sweet water with a stomachache, the Cytoxin was
eliminated. Thereafter, the rats became sick when they drank plain sugar water. Dr. Ader watched and waited to determine how long it would take the rodents to forget that sweet water made them nauseous. In the second month, the rats surprised him by dying.
eliminated. Thereafter, the rats became sick when they drank plain sugar water. Dr. Ader watched and waited to determine how long it would take the rodents to forget that sweet water made them nauseous. In the second month, the rats surprised him by dying.


Noting that one of the side effects of Cytoxin is suppression of the immune system, Dr. Ader observed that although the dead rats were not receiving the drug, they thought that they were. That thought shut down their immune systems and left them vulnerable to the ordinary germs which killed them. Obviously a critical connection existed between the rats’ minds and their immune systems (Ader 6-8). Practical wisdom has always known that there is a connection between the will and the cure. It took an additional six
Noting that one of the side effects of Cytoxin is suppression of the immune system, Dr. Ader observed that although the dead rats were not receiving the drug, they thought that they were. That thought shut down their immune systems and left them vulnerable to the ordinary germs which killed them. Obviously a critical connection existed between the rats’ minds and their immune systems. {{sfn|Ader|1992|p=6-8}} Practical wisdom has always known that there is a connection between the will and the cure. It took an additional six
years to prove what the stoic Lucius Seneca said near the time of Christ, “It is part of the cure to wish to be cured” (Hoyt 668).
years to prove what the stoic Lucius Seneca said near the time of Christ, “It is part of the cure to wish to be cured.”{{sfn|Hoyt|1896|p=668}}


In 1981 it was Neurobiologist Dr. David Felten, (currently a Research and Medical Director at the Beaumont Hospital Research Institute and a former recipient of the MacArthur Foundation genius award), a leading researcher in mind-body medicine, who finally discovered the hardwired connection between the immune system and the central nervous system controlled by the brain. Although ideas of cellular structure and function had existed for some time, they could not be proven because it was impossible to observe submicroscopic compositions like viruses. Advances in technology, including the invention of the electron microscope, greatly expanded the verifiable. The Felten research team led the way in a new field named Psychoneuroimmunology, or PNI. Researchers used fluorescent stain to trace nerves from the brain to bone marrow, lymph nodes, and the spleen. They discovered a network of nerves leading to blood vessels as well as cells of the immune system. At last the connection was visible and scientific research had proven
In 1981 it was Neurobiologist Dr. David Felten, (currently a Research and Medical Director at the Beaumont Hospital Research Institute and a former recipient of the MacArthur Foundation genius award), a leading researcher in mind-body medicine, who finally discovered the hardwired connection between the immune system and the central nervous system controlled by the brain. Although ideas of cellular structure and function had existed for some time, they could not be proven because it was impossible to observe submicroscopic compositions like viruses. Advances in technology, including the invention of the electron microscope, greatly expanded the verifiable. The Felten research team led the way in a new field named Psychoneuroimmunology, or PNI. Researchers used fluorescent stain to trace nerves from the brain to bone marrow, lymph nodes, and the spleen. They discovered a network of nerves leading to blood vessels as well as cells of the immune system. At last the connection was visible and scientific research had proven
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In 1989 Dr. Michael Bishop and Dr. Harold Varmus won the Nobel Prize
In 1989 Dr. Michael Bishop and Dr. Harold Varmus won the Nobel Prize
in Physiology for their cancer discoveries. They established that mutated or
in Physiology for their cancer discoveries. They established that mutated or damaged cells protect the body from their own dysfunction in three ways: they repair themselves, they halt the process of reproduction in order to buy {{pg|447|448}}time to remedy the defects, or if that fails, they can commit cell suicide (called “apoptosis”). If this doesn’t work, the result is uncontrolled proliferation of damaged cells, or cancer.
damaged cells protect the body from their own dysfunction in three ways:
they repair themselves, they halt the process of reproduction in order to buy
{{pg|447|448}}time to remedy the defects, or if that fails, they can commit cell suicide (called “apoptosis”). If this doesn’t work, the result is uncontrolled proliferation of damaged cells, or cancer.


In a ''Harvard Magazine'' article which included excerpts from his book that
In a ''Harvard Magazine'' article which included excerpts from his book that
would be published later that year, Dr. Bishop quotes Norman Mailer, a fellow
would be published later that year, Dr. Bishop quotes Norman Mailer, a fellow
alumnus. He refers to Mailer’s “cancer trigger” theory with a quote from
alumnus. He refers to Mailer’s “cancer trigger” theory with a quote from
''Tough Guys Don’t Dance'': “None of the doctors have a feel for the subject. . . . The way I see the matter, it’s a circuit of illness with two switches. . . . Two terrible
''Tough Guys Don’t Dance'': “None of the doctors have a feel for the subject.... The way I see the matter, it’s a circuit of illness with two switches.... Two terrible things have to happen before the crud can get its start. The first cocks the trigger. The other fires it. I’ve been walking around with the trigger cocked for forty-five years.” {{sfn|Mailer|1984|p=158}} Bishop further explains, “The speaker here was a smoker who died of lung cancer four pages later in Mailer’s novel . . .Mailer’s conservative estimate of two ‘triggers’ has since been revised upward for most cancers, but otherwise, the imagery is on target.” Dr. Bishop, completes the reference with “Norman Mailer gets it,” meaning that Norman Mailer understands how cancer works.{{sfn|Bishop|2003a|p=53}}
things have to happen before the crud can get its start. The first cocks
the trigger. The other fires it. I’ve been walking around with the trigger
cocked for forty-five years” (158). Bishop further explains, “The speaker here was a smoker who died of lung cancer four pages later in Mailer’s novel . . .Mailer’s conservative estimate of two ‘triggers’ has since been revised upward for most cancers, but otherwise, the imagery is on target.” Dr. Bishop, completes the reference with “Norman Mailer gets it,” meaning that Norman Mailer understands how cancer works (Bishop 53).


Anne Harrington, the chair of the History of Science Department at Harvard, writes in her book, The Cure Within, that Mailer authorized his defense lawyers to develop the argument that if he had repressed his rage,
Anne Harrington, the chair of the History of Science Department at Harvard, writes in her book, The Cure Within, that Mailer authorized his defense lawyers to develop the argument that if he had repressed his rage,
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An estimated two million Americans have schizophrenia, a biological condition that affects a person’s ability to think clearly, distinguish reality from fantasy, manage emotions, make decisions, and relate to others. The World Health Organization has identified schizophrenia as one of the ten most debilitating diseases affecting humans. The fact that those who suffer
An estimated two million Americans have schizophrenia, a biological condition that affects a person’s ability to think clearly, distinguish reality from fantasy, manage emotions, make decisions, and relate to others. The World Health Organization has identified schizophrenia as one of the ten most debilitating diseases affecting humans. The fact that those who suffer
from schizophrenia are a population of very heavy smokers (up to 88%) would lead one to expect that they had a high incidence of cancer (Hughes et al. 995). However, the opposite is true. Norman Mailer believed that their
from schizophrenia are a population of very heavy smokers (up to 88%) would lead one to expect that they had a high incidence of cancer {{sfn|Bosworth|2008|p=401}}(Hughes et al. 995). However, the opposite is true. Norman Mailer believed that their
mental illness protected them.
mental illness protected them.


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to make basic decisions about their development and their fate. She says,
to make basic decisions about their development and their fate. She says,
<blockquote>“This is about basic decision making by cells—whether to multiply, move, or change their basic architecture. . . .Cancer and schizophrenia may be strange bedfellows that have similarities at the molecular level. The differences lie in how cells respond to external stimuli: in cancer the molecular system functions to
<blockquote>“This is about basic decision making by cells—whether to multiply, move, or change their basic architecture. . . .Cancer and schizophrenia may be strange bedfellows that have similarities at the molecular level. The differences lie in how cells respond to external stimuli: in cancer the molecular system functions to
speed up the cell and in schizophrenia the system is altered in such a way that causes the cell to slow down.” (qtd. in “Genetics”)</blockquote>
speed up the cell and in schizophrenia the system is altered in such a way that causes the cell to slow down.” {{sfn|Bosworth|2008|p=401}}(qtd. in “Genetics”)</blockquote>


Dr. Daniel Weinberger of NIMH says, “It’s very curious that a brain disorder associated with very complicated human behavior has at a genetic and cellular level a striking overlap with cancer, a very non-behavior related disorder.
Dr. Daniel Weinberger of NIMH says, “It’s very curious that a brain disorder associated with very complicated human behavior has at a genetic and cellular level a striking overlap with cancer, a very non-behavior related disorder.
Understanding these pathways might provide us with some new strategies for thinking about cancer” (qtd. in Reis). Dr. Weinberger adds that future research involving this information will explore ways to reverse these processes—speeding the system up in schizophrenia and slowing it down in cancer—with implications that may help in the treatment of both diseases.
Understanding these pathways might provide us with some new strategies for thinking about cancer” {{sfn|Bosworth|2008|p=401}}(qtd. in Reis). Dr. Weinberger adds that future research involving this information will explore ways to reverse these processes—speeding the system up in schizophrenia and slowing it down in cancer—with implications that may help in the treatment of both diseases.
The most advanced research today is attempting to target cancer cells and
The most advanced research today is attempting to target cancer cells and
turn down their genetic instructions to multiply, invade, occupy, and overcome
turn down their genetic instructions to multiply, invade, occupy, and overcome
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it off. The human cell, with the infinite complexity of its ultramicroscopic
it off. The human cell, with the infinite complexity of its ultramicroscopic
components, has been revealing its secrets to scientists who now envision
components, has been revealing its secrets to scientists who now envision
cancer vaccines made of cells from a victim’s own cancer (Reis).
cancer vaccines made of cells from a victim’s own cancer {{sfn|Bosworth|2008|p=401}}(Reis).


But what about Mailer’s belief that schizophrenia affords protection from
But what about Mailer’s belief that schizophrenia affords protection from
cancer? Does any substantiation exist? Evidence in a study of the tumor suppressor gene APC (adenomatous polyposis coli), which protects people from cancer growth, indicates a significant association between APC and schizophrenia. This gene is thought to confirm susceptibility to schizophrenia and reduce vulnerability to cancer (Cui et al. 675).
cancer? Does any substantiation exist? Evidence in a study of the tumor suppressor gene APC (adenomatous polyposis coli), which protects people from cancer growth, indicates a significant association between APC and schizophrenia. This gene is thought to confirm susceptibility to schizophrenia and reduce vulnerability to cancer {{sfn|Bosworth|2008|p=401}}(Cui et al. 675).


However, one fact must not be overlooked. Cancer is a disease of old age, and the mentally ill die earlier than the general population. In the article{{pg|449|450}}“Dying too Young; Cardiovascular Neglect of the Mentally Ill,” we learn that earlier studies of the mentally ill estimated their life spans to average 20% fewer years than the rest of the population. Recent figures vary from state to state, but are alarmingly higher. In Ohio schizophrenics average a loss of
However, one fact must not be overlooked. Cancer is a disease of old age, and the mentally ill die earlier than the general population. In the article{{pg|449|450}}“Dying too Young; Cardiovascular Neglect of the Mentally Ill,” we learn that earlier studies of the mentally ill estimated their life spans to average 20% fewer years than the rest of the population. Recent figures vary from state to state, but are alarmingly higher. In Ohio schizophrenics average a loss of
thirty-two years of life. As a rule, they take poor care of themselves, have an unhealthy lifestyle, and suffer from metabolic syndrome (idle, overweight,
thirty-two years of life. As a rule, they take poor care of themselves, have an unhealthy lifestyle, and suffer from metabolic syndrome (idle, overweight,
poor nutrition) (Nasrallah). It is possible that many of them do not live long enough to suffer from cancer.
poor nutrition).{{sfn|Nasrallah|2007}} It is possible that many of them do not live long enough to suffer from cancer.
Mailer’s newly discovered handwritten hypothesis, which connects “impotent
Mailer’s newly discovered handwritten hypothesis, which connects “impotent
emotion” and cancer, draws attention to the feeling we are most likely
emotion” and cancer, draws attention to the feeling we are most likely
to label “stress.” The bane of modern humankind, stress causes a myriad of
to label “stress.” The bane of modern humankind, stress causes a myriad of
toxic effects. “When the weight of impossible desire is suffered within, the tension becomes acute and the cells live at the edge of rebellion.” According to Mailer, they may “secede from the body or face their death.” It is an impossible situation. “Man is made of mind and body” and Mailer concludes, when the situation “becomes intolerable, either the mind or the body must divide itself from the whole” (Mailer, “Note”).
toxic effects. “When the weight of impossible desire is suffered within, the tension becomes acute and the cells live at the edge of rebellion.” According to Mailer, they may “secede from the body or face their death.” It is an impossible situation. “Man is made of mind and body” and Mailer concludes, when the situation “becomes intolerable, either the mind or the body must divide itself from the whole.” {{sfn|Mailer|n.d.}}


It is interesting that a Dissociative State (a term used in mental illness) can be a temporary condition that follows a period of high stress. It may involve a sudden disappearance which includes travel or wandering and sometimes the establishment of a new identity. The missing period is called a Fugue.
It is interesting that a Dissociative State (a term used in mental illness) can be a temporary condition that follows a period of high stress. It may involve a sudden disappearance which includes travel or wandering and sometimes the establishment of a new identity. The missing period is called a Fugue.
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passion of his opinions.
passion of his opinions.


===Citations===
{{Reflist|15em}}


===Works Cited===
===Works Cited===
{{Refbegin|indent=1|20em}}
{{Refbegin|indent=1|20em}}
* {{cite journal |last=Ader |first=Dr. Robert |title=On the Clinical Relevance of Psychoneuroimmunology  |journal=Clinical Immunology and Immunopathology |volume=64.1 |date=1992|pages=6-8 |ref=harv }}
* {{cite journal |last=Ader |first=Dr. Robert |title=On the Clinical Relevance of Psychoneuroimmunology  |journal=Clinical Immunology and Immunopathology |volume=64.1 |date=1992|pages=6-8 |ref=harv }}
* {{cite journal |last=Bell |first=Laura |date=2008 |title=Medicine’s New Epicenter? Epigenetics  |journal=Cure: Cancer Updates, Research & Education ||volume=Winter 2008|publisher=CURE Media Group |ref=harv }}
* {{cite book |last=Bishop |first=J. Michael |date=2003a |title=How to Win the Nobel Prize: An Unexpected Life in Science |location=Cambridge |publisher=Harvard |ref=harv }}
* {{cite magazine |last=Bishop |first=J. Michael |authormask=1 |date=2003b |title=What Causes Cancer; Genetic Sloppiness, the Cellular ‘Social Contract’ and Malignancy  |magazine=Harvard Magazine ||volume=March-April |pages=49+ |ref=harv }}
* {{cite magazine |last=Bosworth |first=Patricia |date=2008 |title=Mailer’s Movie Madness  |magazine=Vanity Fair |pages=397+ |ref=harv }}
* {{cite book |last=Hoyt |first=J.K. |date=1896 |title=The Cyclopedia of Practical Quotations: English, Latin, and Modern Foreign Languages |location=New York |publisher=Funk and Wagnalls |ref=harv }}
* {{cite journal |last=Nasrallah |first=Henry A. |date=2007 |title=Dying Too Young: Cardiovascular Neglect of the Mentally Ill |journal=Current Psychiatry Online. ||volume=January 2007 |publisher=Quadrant HealthCom Inc|ref=harv }}
* {{cite book |last=Mailer |first=Norman |date=1988 |chapter=An Interview with Norman Mailer |title=Conversations with Norman Mailer |editor-last=Lennon |editor-first=J. Michael|location=Jackson |publisher=UP of Mississippi |pages=39-51|ref=harv }}
* {{cite book |last=Mailer |first=Norman |authormask=1 |date=n.d. |title=Note on Cancer  |publisher=Collection of J. Michael Lennon |ref=harv }}
* {{cite book |last=Mailer |first=Norman |authormask=1 |date=1984|title=Tough Guy's Don't Dance|location=New York |publisher=Random House |ref=harv }}


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